In animal experiments, through the mouth of natural lycopene median lethal dose (medianlethaldose, LD50) are 5000 mg/kgBW. 4 weeks for the synthesis of lycopene, lavage the highest dose of 1000 mg/kgBW lavage and 13 akba boswellic acid weeks 500 mg/kgBW no positive finding. Given 1000 mg/kgBW rats daily doses of lycopene 100 days, or to give 20 mg daily/kgBW lycopene 200 days, did not observe any toxic reaction caused by the subjects content. Feed dog (100 mg/kgBW lycopene 192 days, in addition to the liver and kidney was observed a slight pigmentation, did not observe any toxic effects. In rat feeding experiment, dose group (50 mg/kgBW) in serum alanine aminotransferase (ALT) alanineaminotransferase, and aspertate aminotransferase (AST) aspartatetransaminase, reduced, and high dose group (250 mg/kgBW) of ALT and AST are higher, and after the stop taking 13 weeks, aspertate aminotransferase activity recovered, but cereal third transaminase is only partially restored, to 50 mg/kgBW was not observed harmful effect level (NOAEL NoObservedAdverseEffectLevel). In the use of rats (maximum dose of 3000 mg/kgBW) and rabbit (the highest dose of 2000 mg/kgBW) on the reproductive and developmental toxicity of no positive findings in the study. Lycopene genetic toxicity experiment (micro nuclear test in vivo, TK gene mutation experiment, chromosome aberration test, etc.) showed that it has no mutagenicity.
Lycopene and reduce radiation or skin by ultraviolet (UV) damage, and other functions. When the UV light skin, the skin of lycopene combined with UV produce free radicals, protect skin from damage, and irradiation compared to UV skin, lycopene decreased by 31% ~ 46%, other carnosic acid price component content is almost the same. Research has shown that through regular intake of foods rich in lycopene can against UV, avoid the UV irradiation have lupus. Lycopene can also quenching free radicals of skin cells, has obvious fading effect to senile plaques.
Lycopene can activate the immune cells that protect the phagocytes from oxidative damage, promote T, B lymphocyte proliferation, the function of T cells, stimulating effect on promoting and inhibiting inflammation glucosamine sulfate and chondroitin sulfate medium to generate some interleukin. The study found that moderate doses of lycopene capsules, can improve human immunity, reduce damage of acute exercise on immunity.
Mammals can't synthesis of lycopene by oneself, must be obtained from vegetables and fruits. Lycopene mainly exist in the food, such as tomatoes, watermelon, grapefruit and guava. Content of lycopene in tomato and varies with the variety and maturity. The higher the maturity, the higher lycopene content. Fresh ripe tomato lycopene content in general is 31 ~ 37 mg/kg, often edible tannic acid astringent lycopene content in tomato juice/sauce according to different concentration and the producing method of about 93 ~ 290 mg/kg, higher lycopene content in fruit and guava (about 52 mg/kg), watermelon (about 45 mg/kg), grapefruit (14.2 mg/kg), etc. Carrots, pumpkins, lee, persimmon, peach, mango, pomegranate, grapes and other fruits and vegetables are available in a small amount of lycopene (0.1 ~ 1.5 mg/kg).
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